Cancer Res. A 5-year DRFS of 97.5 % (92.8 to 100.0 %) was observed in these neoadjuvant-treated and clinically node-negative patients predicted to be low risk by ROR-P (i.e., 57.4 % of Luminal A tumors with clinically node-negative disease). Fort Washington, PA: NCCN; 2018. J Clin Oncol. Tinzl M, Marberger M, Horvath S, Chypre C. DD3PCA3 RNA analysis in urine--a new perspective for detecting prostate cancer. Hematol Oncol Clin North Am. Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein. Silver Spring, MD: FDA; September 7, 2016. Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al. Krane JF, Cibas ES, Endo M, et al. 2008;179(2):478-484; discussion 484. Noon et al (2010) stated that renal cell carcinoma (RCC) is the most common type of kidney cancer and follows an unpredictable disease course. National Horizon Scanning Centre (NHSC). 2015;2:343-348. Lopresti A, Malergue F, Bertucci F, et al. Edmonton, ON: Program in Evidence-Based Care, Cancer Care Ontario; November 20, 2013. Am J Ophthalmol. Bournaud C, Descotes F, Decaussin-Petrucci M, et al. It is unclear whether a similar field of injury exists in people who have never smoked or in very light smokers who have lung cancer and whether the field of injury persists after tumor resection; further studies are needed to evaluate these questions; these investigators considered bronchoscopy to be "diagnostic" only when the procedure yielded a lung-cancer diagnosis. 2009;18(10):OF1-OF6. Sanda MG, Chen RC, Crispino T, et al. 2017;16(11):2598-2608. London, UK: NICE; May 2016. Locker GY, Hamilton S, Harris J, et al; ASCO. 2010;56(2):327-329. Oncology Diagnostics [website]. Eur Urol. TERT promoter mutations identify a high-risk group in metastasis-free advanced thyroid carcinoma. There is emerging evidence for the clinical validity of ctDNA testing regarding identification of candidates for targeted therapies, prediction of therapeutic response, early detection of recurrence, resistance mutation detection, measuring genetic heterogeneity, tumor burden monitoring, and risk stratification. Ovarian cancer: Screening, treatment, and followup. EndoPredict gene expression profiling assay for assessing risk of breast cancer recurrence. Thus, the results might have differed if ER, PR, and HER2 status had been centrally confirmed. CD 31 immunostaining, for diagnosis of angiosarcoma. 2012;110(1):56-62. Cooperberg MR, Davicioni E, Crisan A, et al. Decipher genomic classifier measured on prostate biopsy predicts metastasis risk. Management decisions made by physician assistants and nurse practitioners in cutaneous malignant melanoma patients: Impact of a 31-gene expression profile test. 2015;1(5):582-591. et al., A biopsy-based 17-gene genomic prostate score as a predictor of metastases and prostate cancer death in surgically treated men with clinically localized disease. Issue 179. Rev Urol. 2015;149(1):249-251. 2014;71(6):1083-1092. Influence of a genomic classifier on post-operative treatment decisions in high-risk prostate cancer patients: Results from the PRO-ACT study. Washington, DC: ACOG; November 2016. Clinical implications of plasma-based genotyping with the delivery of personalized therapy in metastatic non-small cell lung cancer. 2004;6(6):258-261. 1997;16(4):354-360. these researchers did not assess the accuracy of a model incorporating the classifier in combination with clinical variables. Eur J Cancer Prev. 2009;27(15):2503-2508. Washington, DC: ACOG; February 25, 2004. A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: An European Research Initiative on CLL study. Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies. 2018;90(5):3058-3066. Among patients with possible or inconsistent UIP on high resolution computed tomography (HRCT), the RNA molecular test showed a positive predictive value of 81 % (95 % CI 54-96) for biopsy-proven UIP. cfDNA can be especially useful when tumor tissue is unavailable or insufficient for testing. Am J Gastroenterol. 2018. Fort Washington, PA: NCCN; 2019. Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy? Berlin, Germany; March 21-24, 2007. Fourth, they used the pathological data as provided in each publication and different definitions and cut-offs might have been used to determine the positivity of each biomarker. Warren, NJ: Veridex; 2005. Expression of galectin-3 in pancreatic ductal adenocarcinoma. AETSA 2013/3. 2003;44:8-16. 2009;150(9):647-649. Clin Obstet Gynecol. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. Lehmann BD, Pietenpol JA. Carlsson SV, Roobol MJ. Hamamura K, Shiratori Y, Shiina S, et al. 1999;30(4):669-673. Coleman RL, Herzog TJ, Chan DW, et al. Meleth S, Reeder-Hayes K, Ashok M, et al. NCCN: Fort Washington, PA. National Comprehensive Cancer Network (NCCN). Waltham, MA: UpToDate; reviewed January 2017a. Repeat testing is considered experimental and investigational, ROS-1 to predict response to crizotinib (Xalkori) for the treatment of non-small cell lung cancer (NSCLC), Steroid hormone receptor status in both pre-menopausal and post-menopausal members to identify individuals most likely to benefit from endocrine forms of adjuvant therapy and therapy for recurrent or metastatic breast cancer, Targeted hematologic genomic sequencing panel (5-50 genes) for myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN), Targeted solid organ genomic sequencing panel (5-50 genes) for non-small cell lung cancer (including Oncomine Dx Target Test (Thermo Fisher Scientific, Carlsbad, CA)), T-cell receptor gene rearrangements (TRA@, TRB@, TRD@, TRG@) for T-cell prolymphocytic leukemia, T-cell large granular lymphocytic leukemia, nasal type extranodal NK/T-cell lymphoma, peripheral T-cell lymphoma, primary cutaneous CD30+ T-cell lymphoproliferative disorders, Castleman's disease, mycosis fungoides/Sezary syndrome, ThyGeNext/ThyGenX (formerly Mirinform Thyroid) for assessing fine needle aspiration samples from thyroid nodules that are indeterminate; experimental for other indications. Rapid Response Report. The MyMRD is a hotspot panel that detects all classes of variants identified in a precisely defined set of targets that commonly drive myeloid malignancies including AML, MPN and MDS. National Comprehensive Cancer Network (NCCN). Horizon Scanning Technology Briefing. 2017;3(8):1085-1093. U.S. Food and Drug Administration (FDA). National Comprehensive Cancer Network (NCCN). Cancer. Carlsbad, CA: Thermo Fisher Scientific; 2017. Data analysis was performed from March 1, 2009 to June 23, 2018. Clinical outcome prediction by microRNAs in human cancer: A systematic review. Toronto, ON: Cancer Care Ontario; June 8, 2016. Provista Life Sciences. They included studies if they met all 4 of the following criteria: The authors noted that there are several important limitations to this study: CPB 0715 - Pharmacogenomic and Pharmacodynamic Testing), CPB 0313 - Trastuzumab (Herceptin and biosimilars), Trastuzumab and Hyaluronidase-oysk (Herceptin Hylecta), CPB 0715 - Pharmacogenetic and Pharmacodynamic Testing, CPB 0227 - BRCA Testing, Prophylactic Mastectomy, and Prophylactic Oophorectomy. London, UK: NICE; December 2009. However, there is a lack of evidence that data generated by this test would alter management of the cancers for which the testing is indicated such that clinical outcomes are improved. Int J Hyg Environ. Saad F. UPM3: Review of a new molecular diagnostic urine test for prostate cancer. JAMA Oncol. A specific CNI index obtained by massive parallel sequencing discriminated those patients with prostate cancer from both healthy controls and men with benign prostatic disease. These researchers examined the performance of 4 different targeted NGS gene panels based on their technical features and clinical utility. Front Biosci (Landmark Ed). 2015;6(33):34221-34227. Curr Med Res Opin. 1990;85:350-355. Occult primary. Update on horizon scans of genetic tests currently available for clinical use in cancers. The detection system builds on the secondary. 2002;62:2695-2698. However, some caution should be made with any novel test, including the requirement to validate the results in other independent cohorts and racially diverse groups. Gynecol Oncol. 2008;14(20):6602-6609. 1999;162(1):53-57. It is now commonly used as multiple secondaries can bind to a single primary to amplify the staining intensity. Recent Results Cancer Res. 2011;117(6):1289-1297. Onken MD, Worley LA, Char DH, et al. Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy. Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses. Cancer. Health Technol Assess. 2019 Dec 26 [Epub ahead of print]. Identification of high-risk cutaneous melanoma tumors is improved when combining the online American Joint Committee on Cancer Individualized Melanoma Patient Outcome Prediction Tool with a 31-gene expression profile-based classification. 2016;32(6):1161-1165. Magy Onkol. National Comprehensive Cancer Network (NCCN). Comparison of MammaPrint and TargetPrint results with clinical parameters in German patients with early stage breast cancer. Kushnir VM, Mullady DK, Das K, et al. Fort Washington, PA: NCCN; 2018. 2015;193(4 Suppl):e2-e3. Neoplasia. UpToDate [online serial]. Odegaard JI, Vincent JJ, Morti SA, et al. 1996;91(7):1380-1383. 2007;25(33):5287-5312. Rasamny JJ, Allak A, Krook KA, et al. Friboulet L, Olaussen KA, Pignon JP, et al. 2019;14(9):e0222336. 2015;2(4):181-189. These researchers retrospectively studied the urinary steroid profiles of 5 patients with adrenocortical carcinoma at presentation and at follow-up, and compared these results with those from 76 patients with benign adrenocortical adenoma and 172 healthy controls. Semin Liver Dis. Motility-related protein-1/CD9 expression in head and neck squamous cell carcinoma Head Neck. Circulating tumor cells and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for outcome prediction in metastatic breast cancer. National Institutes of Health (NIH), Early Detection Research Network (EDRN). Comparison of PAM50 risk of recurrence score with Oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. Blood-based and urinary prostate cancer biomarkers: A review and comparison of novel biomarkers for detection and treatment decisions. The authors concluded that the findings of this study suggested that ctDNA analysis after surgery is a promising prognostic marker in stage III colon cancer. National Comprehensive Cancer Network (NCCN). Rev Urol. Available at: http://www.sgo.org/publications/OvarianCancerSymptoms.pdf. Ross AE, Johnson MH, Yousefi K, et al. 2004;10(10):3291-3300. Thomas KW, Gould MK. Anticancer Res. Evidence Report/Technology Assessment No. 2013;31(5):566-71. London, UK: NICE; March 2015. Screening for breast cancer. Member and physician (prior to testing) have discussed the potential results of the test and agree to use the results to guide therapy. 2008;8(169). ; MINDACT Investigators.. 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer. Singhal U, Morgan TM, Tosoian JJ. Chicago, IL: BCBSA; November 2010;25(1). 2016;7(9):9707-9717. NPJ Breast Cancer. Use of biomarkers to guide decisions on adjuvant systemic therapy for women with early-stage invasive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline. (NCCN) Bone cancer. Krop I, Ismaila N, Andre F, et al. Available at: https://www.integratedoncology.com/test-menu/omniseq-advance-assay/4e3e0db4-7a52-4c5e-a677-4bc58fc7606f. Identification of patients at risk of metastasis using a prognostic 31-gene expression profile in subpopulations of melanoma patients with favorable outcomes by standard criteria. 2013;31(14):1775-1781. Klein EA, Stephenson AJ, Raghavan D, Dreicer R. Systems pathology and predicting outcome after radical prostatectomy. 1997;40:350-355. J Drugs Dermatol. Multidrug resistance in lymphomas. Given the heterogeneity of the models, they can not be considered comparable. A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response. 2016;22(5):622-639. Fort Washington, PA: NCCN; 2018. CA Cancer J Clin. Cancer. Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer. Current concepts in biomarker technology for bladder cancer. Pancreatic cystic neoplasm: The role of cyst morphology, cyst fluid analysis, and expectant management. Fort Washington, PA: NCCN; 2016. Accessed July 6, 2007. 2017;89(4):2488-2496. Newcomb LF, Zheng Y, Faino AV, et al. 2015;373(3):243-251. National Institute for Health and Care Excellence (NICE). Both DAB and AP red are sometime used on the same tissue section to allow the pathologist to visualize two antigens on the one side. Cancer Care Ontario. 2016;34(18):2182-2190. Ovarian cancer screening tests: Safety communication - FDA recommends against use. Evaluating the clinical impact of a genomic classifier in prostate cancer using individualized decision analysis. Moreover, these researchers stated that prospective validation is needed before this classification can be used clinically. Tesarova P, Kalousova M, Zima T, Tesar V. HMGB1, S100 proteins and other RAGE ligands in cancer - markers, mediators and putative therapeutic targets. Monzon FA, Koen TJ. Technology Assessment Report. Breast tumor is estrogen receptor positive or progesterone receptor positive; Breast tumor is HER2 receptor negative (Rationale: adjuvant chemotherapy with trastuzumab (Herceptin) is considered to be medically necessary regardless of Mammaprint score for HER2 receptor positive lesions); Member is determined to be at "high clinical risk" of recurrence using, Member and physician (prior to testing) have discussed the potential results of the test and agree to use the results to guide therapy. Biomarkers in pulmonary nodule diagnosis. A gene-expression signature as a predictor of survival in breast cancer. This will ensure the consistency of results. Mol Diagn Ther. HER-2 and topoisomerase II as predictors of response to chemotherapy. Ovarian malignancy risk stratification of the adnexal mass using a multivariate index assay. They stated that there are potential limitations to this study, including the modest sample size of patients with recurrent CRC and the analysis of multiple patient subsets. Adelaide, SA: Adelaide Health Technology Assessment (AHTA) on behalf of National Horizon Scanning Unit (HealthPACT and MSAC); 2005. Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer. Little J, Wilson B, Carter R, et al. The amount of staining, the staining pattern and the location of staining (cell cytoplasm nucleus or membrane) all provide information for the diagnosing pathologist. Sum of peak intensities outperforms peak area integration in iTRAQ protein expression measurement by LC-MS/MS using a TripleTOF 5600+ platform. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: An update for the U.S. Preventive Services Task Force. A 17-gene panel for prediction of adverse prostate cancer pathologic features: Prospective clinical validation and utility. Further improvements in maintaining consistency to correctly control for these factors could be pursued. In an editorial that accompanied the afore-mentioned study by Silvestri et al (2018), Al Nasrallah and Sears (2018) stated "So, is it time to put away the biopsy needle? The triple-negative subtype of IBC (TN-IBC) is particularly aggressive. Adopted on May 17, 1996 by the American Society of Clinical Oncology. NCCN Clinical Practice Guidelines in Oncology v.2.2011. Cancer Med. Determination of sequential mutation accumulation in pancreas and bile duct brushing cytology. Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS). Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: Biomarker for treatment selection exclusion or inclusion? Arch Pathol Lab Med. In the clinical model the hazard ratio for death from prostate cancer was 9.8 (95 % CI 2.8 to 34.3, p < 0.001) in men with an annual PSA velocity of more than 2 ng/ml versus an annual PSA velocity of 2 ng/ml or less; similarly, the hazard ratio was 12.8 (95 % CI 3.7 to 43.7, p < 0.001) in the pathological model. 2017;12(7):e81-e84. Oncotype Dx Breast (also known as 21 gene RT-PCR test) to assess necessity of adjuvant chemotherapy in females or males with recently diagnosed breast tumors, where all of the following criteria are met: Member and physician (prior to testing) have discussed the potential results of the test and agree to use the results to guide therapy (i.e., member will forgo adjuvant chemotherapy if Oncotype Dx Breast score is low). Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer. Seifert JK Morris DI. Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies. 2019;20(1):30-36. 2007 Jun;43(9):1348-1360. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Reduced rate of repeated prostate biopsies observed in ConfirmMDx clinical utility field study. Prostate cancer. 2015;29(11):1302-1308. Hochheiser L, Hornberger J, Turner M, Lyman GH. Pirtskalaishvili G, Konety BR, Getzenberg RH. Piotrowska Z, Drapkin B, Engelman JA, et al. Oncotype®. Bast RC Jr, Hortobagyi GN. Serial ctDNA analyses revealed disease recurrence up to 16.5 months ahead of standard-of-care radiologic imaging (mean of 8.7 months; range of 0.8 to 16.5 months). Molecular analysis of centrifugation supernatant fluid from pancreaticobiliary duct samples can improve cancer detection. Is DD3 a new prostate-specific gene? Chromogranin A â A protein found inside neuroendocrine cells, which releases chromogranin A and other hormones into the blood. Plasma ddPCR for EGFR or KRAS mutations revealed findings nearly identical to those of plasma NGS in 21 of 22 patients, with high concordance of variant allele fraction (r = 0.98). 2005;15 Suppl 3:274-281. Caris Target Now⢠molecular profiling service for solid malignant tumours. Eskander RN, Carpenter BA, Wu HG, Wolf JK. Plasseraud KM, Cook RW, Tsai T, et al. Armstrong AJ, Halabi S, Luo J, et al. 321KPLDGEYFTLQIR333 (p53) and 327ENWLPEDK334 (MDM2) were selected as surrogate peptides in the targeted analysis. Nathan P, Cohen V, Coupland S, et al. Wang and co-workers (2020) noted that surgical resection is the primary treatment for patients with non-metastatic CRC. Cowling T, Loshak H. An overview of liquid biopsy in screening and early detection of cancer. Zhang W, Zhong T, Chen Y, et al. Bradley LA, Palomaki G, Gutman S, et al. Arch Pathol Lab Med. Screening for ovarian cancer: Recommendations and rationale. Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors. Butts CA. National Comprehensive Cancer Network (NCCN). Cyclin D1 and FADD as biomarkers in head and neck squamous cell carcinoma. 2006;101(11):2493-2500. National Comprehensive Cancer Network (NCCN). Omaha, NE: eMedicine.com. In an editorial that accompanied the afore-mention study, Helfand (2020) stated that "Overall, the results appear to be promising new PCa biomarkers for each of these tests. Cost-effectiveness analysis of a multivariate index assay compared to modified American College of Obstetricians and Gynecologists criteria and CA-125 in the triage of women with adnexal masses. Adopted on November 7, 1997 by the American Society of Clinical Oncology. Eur Urol. Uterine neoplasms. KotÅowska A, MaliÅski E, Sworczak K, et al. Urol Oncol. 2006;101(9):2038-2043. Goodrich ST, Bristow RE, Santoso JT, et al. Society of Gynecologic Oncologists statement regarding OvaCheckâ¢. GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients. Przygodzki RM, Finkelstein SD, Langer JC, et al. Nielsen KV, Ejlertsen B, Møller S, et al. Colon cancer. Sgroi DC, Sestak I, Cuzick J, et al. The updated Afirma Genomic Sequencing Classifier and XA reports aimed to optimize the understanding of these contributions, including decisions regarding observation versus surgery, the need for diseaseâspecific pre-operative testing, associated neoplasm types, prognostics, the identification of molecular targets for systemic therapy, and the recognition of potential hereditary syndromes. Lin X, Zhu B, Finkelstein SD, et al. 2019;29(3):311-321. 1999;44(5):1039-1046. Boily G, Boulanger J, Goulet S, et al. FDA raises regulatory issues. 2014;20(8):e302-e310. Leuk Res. Konety B, Zappala SM, Parekh DJ, et al. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. Rockville, MD: FDA; March 2, 2004. 2009;13(1):11-14. J Clin Oncol. The level of nuclear counterstain is carefully regulated and standardized so as not to obscure positive staining. Biologic determinants of tumor recurrence in stage II colon cancer: Validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581. Pancreatology. Cancer Chemother Pharmacol. The results of the current study demonstrated a statistically significant correlation between the concentration changes of cfDNA and cftDNA and response to treatment, which was assessed by imaging. 2018;8(6):60. Esserman L, Yau C. Rethinking the standard for ductal carcinoma in situ treatment. 1999;45 Suppl 6:VI1-VI22. Hainsworth JD, Rubin MS, Spigel DR, et al. 2008;26(5):736-744. 4000). J Clin Endocrinol Metab. 2015;1(7):881-883. 2008;247(1):136-142. Miyake M, Nakano K, Ieki Y, et al. 2015;67(2):326-333. J Chemother. J Oncol. Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma. 2016;18(7):660-665. Available at: https://edrn.nci.nih.gov/biomarkers/mips-mi-prostate-score-urine-test. 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O'Sullivan P, Sharples K, Dalphin M, et al. NCCN Clinical Practice Guidelines in Oncology, version 1.2019. Pre-treatment breast cfDNA was detected in patients with localized disease with a sensitivity of 80 % at 97 % specificity. Genet Med. Because of the heterogeneity regarding populations, outcomes and study type, meta-analyses were not undertaken and the results are presented in tabulated format with a narrative synthesis of the results. 2016;150(1):210-218. Impact of a 31-gene expression profiling test for cutaneous melanoma on dermatologists' clinical management decisions. Stoyanova R, Pollack A, Takhar M, et al. diagnostic assessment of myeloproliferative disorders in children; quantitative assessment of JAK2-V617F allele burden subsequent to qualitative detection of JAK2-V617F. 2011;7(2):94-99. Atlanta, GA: ACS; June 14, 2007. Clin Invest Med. Moreover, these researchers stated that further research is needed to examine the effect of incorporating this test into the diagnostic algorithm for nodule management in the hope of reducing unnecessary procedures in patients without cancer. Clin Transl Oncol. JCO Precis Oncol. Bloomington, MN: ICSI; September 2004. Gene expression analysis for prostate cancer management. Fischer RN, Wolf J. Tumor mutation burden as emerging biomarker in non-small cell lung cancer and beyond. 2015;47(2):136-142. 2017;35(13):1437-1443. Chen L, Chen M, Chen J. 2010;12(4):461-468. British Society of Gastroenterology. An additional 695 blinded FNAs were used to define performance for fusions between whole-transcriptome RNA-seq and targeted RNA-seq. Wild C, Grössmann N. FoundationOne CDx: Genetic profiling of solid tumours. postmenopausal with elevated CA 125 level, ultrasound findings suggestive of malignancy, ascites, a nodular or fixed pelvic mass, or evidence of abdominal or distant metastases; premenosausal with very elevated CA 125 level, ultrasound findings suggestive of malignancy, ascites, a nodular or fixed pelvic mass, or evidence of abdominal or distant metastases; premenopausal or postmenopausal with an elevated score on a formal risk assessment test such as the multivariate index assay, risk of malignancy index, or the Risk of Ovarian Malignancy algorithm or one of the ultrasound-based scoring systems from the International Ovarian Tumor Analysis group. HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease. 2. van de Vijver, He YD, vanât Veer LJ, et al. In: Guide to Clinical Preventive Services. NCCN Clinical Practice Guidelines in Oncology, Version 3.2014. 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